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Degenerative Myelopathy (DM)

Degenerative myelopathy (DM) is an inherited neurologic disorder of dogs characterized by gradual muscle wasting and loss of coordination typically beginning in the hind limbs.

Agouti (A Locus)

The Agouti Signaling Protein (ASIP) gene interacts with the MC1R gene to control red and black pigment switching in dogs, affecting amount, type, and distribution of the two pigments.

Coat Length

Five recessive variants in the fibroblast growth factor-5 (FGF5) gene are associated with long hair phenotypes in dogs.

Curl

A variant in the Keratin-71 gene is associated with curly hair in dogs. Dogs with the curl variant have curly coats or wavy coats depending on how many copies of the variant they possess.

Degenerative Myelopathy (DM)

Degenerative myelopathy (DM) is an inherited neurologic disorder of dogs characterized by gradual muscle wasting and loss of coordination typically beginning in the hind limbs.

Dilute (D Locus/Blue)

Several gene variants are known to produce dilute coloration in dogs. Colors are lightened (diluted) to paler shades as a result of the variants' effects on pigmentation.

Dominant Black (K Locus)

The Dominant Black gene (K Locus) affects pigment switching between eumelanin (black) and phaeomelanin (red or yellow) by interacting with the Agouti and MC1R genes.

Furnishings and Improper Coat

A dominant variant of the R-spondin-2 gene produces the longer mustache and eyebrows seen in wire-haired dogs and other breeds.

Hyperuricosuria (HUU)

Hyperuricosuria is an inherited disorder characterized by elevated levels of uric acid in the urine that can lead to the formation of bladder/kidney stones.

Intensity Dilution

The intensity coat color gene variant causes an extreme dilution of phaeomelanin (red or yellow pigment), resulting in a cream to white coat in dogs.

MC1R including Mask, Grizzle, and Red/Cream (E Locus)

The melanocortin 1 receptor (MC1R) gene controls production of the pigments eumelanin (black) and phaeomelanin (red/yellow). Six known variants of this gene are responsible for producing markings and coat colors including melanistic mask, grizzle/domino, black, and shades of red/yellow.

Merle

Merle is an incompletely dominant coat color pattern characterized by irregularly shaped patches of diluted pigment and solid color.

Parentage/Genetic Marker Report

This DNA-based parentage test uses microsatellite marker analysis to compare the DNA profile of an offspring to the profiles of possible parents.

Piebald/White Spotting (S Locus)

White spotting patterns that occur in many dog breeds do not have a uniform genetic basis, and the genetics are complex. In piebald/parti/random white spotting, the extent of white pattern expression varies, and markings are often asymmetrical.