Toy Poodle

New Test Available ?? - GM2 Gangliosidosis in the Toy Poodle

GM2 gangliosidosis is a fatal neurodegenerative lysosomal storage disease that affects dogs. A genetic variant causing GM2 gangliosidosis has been identified in certain lineages of Toy Poodles.

Affected dogs typically display neurological signs that begin at 9-12 months of age and may include tremor, incoordination or stiff gait, and difficulty eating. Neurological deterioration progresses over 6-12 months, ultimately resulting in death.

The disease is inherited in an autosomal recessive manner, meaning that two copies of the disease variant are needed to express disease. DNA testing can determine the genetic status of dogs and allow breeders to make informed decisions to avoid producing affected puppies.

Read more about the test and its applications at