New Test Available - Primary Open-Angle Glaucoma (POAG) in the Petit Basset Griffon Vendeen
Primary open-angle glaucoma (POAG) is a type of glaucoma that typically progresses gradually and without obvious signs of pain. A genetic inversion disrupting the ADAMTS17 gene is associated with POAG in the Petit Basset Griffon Vendeen. POAG is characterized by elevated intraocular pressure (increased pressure inside the eye) and partial dislocation of the lens. Pain does not seem to be a common feature so that owners only become aware of the disorder at a later stage when the eye becomes enlarged and/or vision problems are noticed, which occur due to retinal and optic nerve degeneration. The prevalence of glaucoma in the breed was determined to be 10.4% and the disorder is typically diagnosed around 3-4 years of age.
DNA testing for primary open-angle glaucoma can determine the genetic status of dogs. Dogs with one copy of the POAG allele are normal but are carriers. Matings between two carrier dogs may, on average, produce 25% of puppies with primary open-angle glaucoma.
Read more about the test and its applications at https://vgl.ucdavis.edu/test/poag-petit-basset-griffon-vendeen