Naked Foal Syndrome in Akhal-Teke

Quick Summary

Naked foal syndrome (NFS) is an inherited disorder found in the Akhal-Teke breed and is characterized by hairlessness, abnormal teeth development, digestive disorders, persistent diarrhea, and laminitis-like problems.

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Phenotype: Naked foal syndrome (NFS) is an inherited disorder found in the Akhal-Teke breed and is characterized by hairlessness, abnormal teeth development, digestive disorders, persistent diarrhea, and laminitis-like problems.

Mode of Inheritance: Autosomal recessive

Alleles: N = Normal/Unaffected, NFS = Naked foal syndrome

Breeds appropriate for testing: Akhal-Teke

Explanation of Results:

  • Horses with N/N genotype will not have naked foal syndrome and cannot transmit this naked foal syndrome variant to their offspring.
  • Horses with N/NFS genotype will not have naked foal syndrome, but are carriers. They may transmit this naked foal syndrome variant to 50% of their offspring. Matings between two carriers result in a 25% chance of producing an affected foal.
  • Horses with NFS/NFS genotype will have naked foal syndrome, a condition incompatible with life.

Turnaround Time
At least 10 business days; may be delayed beyond 10 business days if sample requires additional testing, or a new sample is requested.
Price

$45 one test per animal

Sample Collection

Horse DNA tests are carried out using cells from the roots of a hair sample (roughly 20-30 hairs).

1. Grab about 10 hairs at the base.

2. Wrap the hairs around your finger and give it a quick pull.

3. Check the ends to make sure the pulled hairs have roots.

4. Repeat the process until you have collected about 20-30 hairs with intact roots.

5. You can choose different places on the mane or tail. NOTE: For foals, we recommend pulling all hairs from the tail only. 

6. Tape the hairs to the submission form and fold the form along the dotted line to protect the sample. Do not use ziploc bags as they can cause condensation that allows mold to grow on the hair.

Hairs with roots

7. Place the folded form containing the sample in a paper envelope and mail it to the laboratory.

 

Additional Details

The molecular basis of the hairlessness or naked foal syndrome (NFS) in Akhal-Teke breed has been identified by researchers in Switzerland. NFS has been known in the breed since 1938. Primary signs of the defect are lack of body, mane, and tail hair, abnormal teeth development, digestive disorders, persistent diarrhea, and laminitis-like problems. NFS is always fatal with most foals dying within weeks of birth, although some have survived to two years of age.

NFS is inherited as an autosomal recessive trait, which means that two copies of the mutation are needed to produce the disease. Carriers of NFS (1 copy of the mutation) are normal but can produce affected foals if bred to another carrier. The mutation associated with NFS is located in the gene ST14 (c.388G>T) and results in a truncated version of the gene, likely causing the improper formation of the epidermal barrier and hair follicle development.

Testing for NFS can help breeders and owners identify carriers of NFS and select mating pairs accordingly to avoid producing affected foals. Matings between two carriers have a 25% chance of producing NFS foals. Given the small population size of the breed, and to avoid further reductions of the gene pool, mating between carriers and normal horses are acceptable as they will not result in NFS foals.