Phenotype: Korat GM1 gangliosidosis causes progressive neurologic dysfunction, including tremors, ataxia, and dysmetria. Disease onset begins around 3 months of age and reaches terminal stage around 9-10 months, at which point blindness and epileptiform seizures are also observed.
Mode of Inheritance: Autosomal recessive
Alleles: N = Normal, GM1k = Korat GM1 gangliosidosis
Breeds appropriate for testing: Korat, Siamese
Explanation of Results:
- Cats with N/N genotype will not have Korat GM1 gangliosidosis and cannot transmit this GM1 variant to their offspring.
- Cats with N/GM1k genotype will not have Korat GM1 gangliosidosis, but are carriers. They will transmit this GM1 variant to 50% of their offspring. Matings between two carriers are predicted to produce 25% kittens with Korat GM1 gangliosidosis.
- Cats with GM1k/GM1k genotype will have Korat GM1 gangliosidosis, a fatal condition.