Phenotype: Cats affected by PK deficiency develop anemia. The anemia is intermittent, the age of onset is variable, and clinical signs are also variable. Symptoms of this anemia can include severe lethargy, weakness, weight loss, jaundice, and abdominal enlargement.
Mode of Inheritance: Autosomal recessive
Alleles: N = Normal, K = PK deficiency
Breeds appropriate for testing: Abyssinian, Australian Mist, Bengal, Domestic Shorthair and Longhair, Egyptian Mau, La Perm, Maine Coon, Norwegian Forest, Savannah, Siberian, Singapura, Somali, Toyger
Explanation of Results:
- Cats with N/N genotype will not have PK deficiency. They cannot transmit this PK deficiency variant to their offspring.
- Cats with N/K genotype will not have PK deficiency, but are carriers. They will transmit this PK deficiency variant to 50% of their offspring. Matings between two carriers are predicted to produce 25% PK deficiency-affected kittens.
- Cats with K/K genotype will have PK deficiency; severity of symptoms cannot be predicted and may be variable. They will transmit this PK deficiency variant to all of their offspring.