News

Mutation Associated with Malignant Hyperthermia (MH) Found to be at Low Frequency but Clinically Significant in Quarter Horse Populations

A new study led by VGL director, Dr. Rebecca Bellone, in collaboration with UC Davis Professor, Dr. Monica Aleman, and University of Minnesota Professor, Dr. Molly McCue, determined that the genetic variant causing malignant hyperthermia (MH) is at a low frequency in Quarter Horses and related breeds, and horses homozygous for the mutation remain undetected.

New Test Available: Congenital Myotonia in Goats

Congenital myotonia (CM) is a heritable neuromuscular disorder that is characterized by a slow relaxation of skeletal muscles following voluntary contraction. Affected animals exhibit sudden muscle stiffness when excited or startled and this stiffness often causes the animal to fall over briefly. 

New Test Available: X-Linked Progressive Retinal Atrophy in Greyhounds

UC Davis School of Veterinary Medicine researchers, Dr. Bannasch and Dr. Thomasy, have identified the likely cause of one form of PRA in racing Greyhounds. The researchers have shared these finding with the VGL pre-publication so that we could more rapidly offer genetic testing to Greyhound breeders.

New Test Available: Progressive Retinal Atrophy (Shetland Sheepdog type)

The Veterinary Genetics Laboratory has launched a new test that is specific to the Shetland Sheepdog: Progressive Retinal Atrophy (Shetland Sheepdog type).

Progressive retinal atrophy (PRA) is a term used to describe a group of inherited disorders of the retina, characterized by progressive retinal degeneration and consequent blindness. More than 20 mutations in various genes have been associated with PRA in dogs, many of which are breed-specific. 

New Test Available: Equine Juvenile Spinocerebellar Ataxia (EJSCA)

Equine Juvenile Spinocerebellar Ataxia (EJSCA) is an inherited neurologic disease that causes ataxia in American Quarter Horses. The variant causing this disease was identified at UC Davis by Dr. Carrie Finno, Gregory L. Ferraro Endowed Director of the UC Davis Center for Equine Health (CEH), and colleagues, and the scientific paper describing this finding is currently in progress. Dr. Finno found that affected foals developed ataxia, or incoordination, between 1 and 4 weeks of age. In most affected foals, the hind limbs appeared to be more severely affected than the front limbs.

New Test Available: Saluki Encephalopathy

Saluki encephalopathy is a neurological disorder caused by Succinic Semialdehyde Dehydrogenase Deficiency (SSADHD) and clinically characterized by early onset of seizures and abnormal behaviors. The condition, also known as central nervous system status spongiosus in Saluki dogs (SSSD), is inherited in an autosomal recessive manner and affected puppies typically display seizures, hypermetria (exaggerated gait), and abnormal behaviors, such as episodes of vocalization, within the first 10 weeks of age.