Shetland Sheepdog

Dermatomyositis (DMS) is an immune-mediated disorder that affects skin and muscle in the Collie and Shetland Sheepdog.

Collie Eye Anomaly (CEA), also known as choroidal hypoplasia, is a heritable disorder that can result in abnormal development of inner structures of the eye. This genetic variant is associated with CEA in multiple breeds.

Progressive retinal atrophy (PRA) is characterized by degeneration of the retina resulting in progressive vision loss leading to total blindness. This Shetland Sheepdog type PRA is caused by a mutation in the CNGA1 gene. This is not the only cause of PRA in the breed.

Multidrug Sensitivity is caused by a deletion in the ABCB1 gene, also known as the multidrug resistance 1 (MDR1) gene, and is characterized by neurotoxicity following the use of certain common drugs. Dogs with two copies of MDR1 will exhibit multidrug sensitivity. Some dogs with 1 copy of MDR1 may also exhibit multidrug sensitivity.

The intensity coat color gene variant causes an extreme dilution of phaeomelanin (red or yellow pigment), resulting in a cream to white coat in dogs.

This DNA-based parentage test uses microsatellite marker analysis to compare the DNA profile of an offspring to the profiles of possible parents.

Progressive rod-cone degeneration (PRCD) is an inherited form of late-onset progressive retinal atrophy (PRA) that has been identified in many dog breeds.

A dominant variant of the R-spondin-2 gene produces the longer mustache and eyebrows seen in wire-haired dogs and other breeds.