Pulmonary Hypoplasia with Anasarca (PHA) in Dexters

Quick Summary

Pulmonary hypoplasia with anasarca (PHA) is a lethal genetic defect characterized by incomplete development of the lungs and severe subcutaneous fluid accumulation, leading to abortion or the birth of a dead calf.

Phenotype: Pulmonary hypoplasia with anasarca (PHA) is a lethal genetic defect characterized by incomplete development of the lungs and severe subcutaneous fluid accumulation, leading to abortion or the birth of a dead calf.

Mode of Inheritance: Autosomal recessive

Alleles: N = Normal/Unaffected, PHAD = Pulmonary hypoplasia with anasarca (Dexter variant)

Breeds appropriate for testing: Dexter, Dexter crosses

Explanation of Results:

  • Cattle with N/N genotype will not have pulmonary hypoplasia with anasarca and cannot transmit this PHA variant to their offspring.
  • Cattle with N/PHAD genotype will not be affected by pulmonary hypoplasia with anasarca, but are carriers. They will transmit this Dexter PHA variant to 50% of their offspring. Matings between two carriers result in a 25% chance of producing a calf with pulmonary hypoplasia with anasarca.
  • Cattle with PHAD/PHAD genotype will have pulmonary hypoplasia with anasarca, a lethal condition. Fetuses with this genotype are expected to naturally abort or be stillborn.
Price

$25 one test per animal

Also available as part of the following packages:

$35 this test + one test from list below
$45 this test + two tests from list below
$55 this test + all tests from list below

Additional Details

Pulmonary hypoplasia with anasarca (PHA) is a lethal genetic defect that leads to abortion or the birth of a dead calf. Associated dystocia can also lead to death of the cow. PHA is characterized by incomplete development of the lungs and severe subcutaneous fluid accumulation. PHA occurs in several breeds such as Dexter, Maine-Anjou Shorthorn, and related composite cattle.

Research by Dr. Jon Beever at the University of Illinois identified the mutations responsible for PHA in cattle. The affected gene is the same for the different breeds, but the specific mutation associated with PHA in Dexter cattle is different from the Maine-Anjou/Shorthorn mutation. PHA has an autosomal recessive mode of inheritance.

This genetic test is specific for the Dexter PHA mutation (PHAD).

 

Note: This test does not detect the Maine Anjou/Shorthorn mutation.
Turnaround Time
2-6 business days
Type of Sample

Species

Type of Test

Results Reported As
Test Results Dexter Pulmonary Hypoplasia with Anasarca (PHA)
N/N Normal. Animal does not have the Dexter PHA mutation.
PHAD/N Carrier. Has one copy of the Dexter PHA mutation. Breeding to another carrier will produce 25% affected calves.
PHAD/PHAD Affected. Has 2 copies of the Dexter PHA mutation.
References

Windsor, P. , Cavnagh, J., & Tammen, I. (2006). Hydrops fetalis associated with pulmonary hypoplasia in Dexter calves. Australian Veterinary Journal, 84(8), 278-281. doi: 10.1111/j.1751-0813.2006.00018.x