Beagle

Several gene variants are known to produce dilute coloration in dogs. Colors are lightened (diluted) to paler shades as a result of the variants' effects on pigmentation.

The Brown gene dilutes eumelanin (black pigment) to brown but does not affect phaeomelanin (red/yellow pigment).

The melanocortin 1 receptor (MC1R) gene controls production of the pigments eumelanin (black) and phaeomelanin (red/yellow). Six known variants of this gene are responsible for producing markings and coat colors including melanistic mask, grizzle/domino, black, and shades of red/yellow.

Pyruvate kinase deficiency (PKDef) is an inherited hemolytic anemia caused by a defect in the enzyme pyruvate kinase. Signs in affected dogs may include lack of energy and fatigue in dogs that appear otherwise fit.

This inherited primary open angle glaucoma in Beagles results from a mutation in the gene ADAMTS10. The condition is characterized by increased pressure in the eye; nerve damage, vision loss, lens subluxation, and blindness may result.

Neonatal cerebellar cortical degeneration in young Beagle puppies is characterized by lack of coordination, broad based stance, loss of balance, and tremors.

Musladin-Lueke Syndrome (MLS) is a genetic disease in Beagles that affects the development and structure of connective tissue across multiple organ systems.

Imerslund-Gräsbeck syndrome (IGS) is a disorder found in Beagles and Border Collies where vitamin B12 is unable to be absorbed through the gut.

Chondrodysplasia is a short-legged phenotype characteristic of many dog breeds. Chondrodystrophy, a separate mutation, also includes a short-legged phenotype as well as premature disc degeneration and increased susceptibility to disc herniation.