Neonatal Cerebellar Cortical Degeneration (NCCD) in Beagles

Quick Summary

Neonatal cerebellar cortical degeneration in young Beagle puppies is characterized by lack of coordination, broad based stance, loss of balance, and tremors.

Phenotype: Neonatal cerebellar cortical degeneration in young Beagle puppies is characterized by lack of coordination, broad based stance, loss of balance, and tremors. The condition is neonatal and onset is noticed at about 3 weeks of age as puppies begin to walk. The severity of the condition is variable among individuals but progression of clinical signs is minimal.

Mode of Inheritance: Autosomal recessive

Alleles: N = Normal, CCD = Neonatal cerebellar cortical degeneration

Breeds appropriate for testing: Beagle

Explanation of Results:

  • Dogs with N/N genotype will not have neonatal cerebellar cortical degeneration and cannot transmit this variant to their offspring.
  • Dogs with N/CCD genotype will not be affected by neonatal cerebellar cortical degeneration, but are carriers. They will transmit this variant to 50% of their offspring. Matings between two carriers are predicted to produce 25% neonatal cerebellar cortical degeneration-affected puppies.
  • Dogs with CCD/CCD genotype will have neonatal cerebellar cortical degeneration.

Results of this test can be submitted to the OFA (Orthopedic Foundation for Animals)

Price

$50 one test per animal
$30 as additional test (same animal)

Panels Available
Additional Details

Inherited neurological degenerative diseases are found in several mammalian species including humans, horses, and dogs. Cerebellar cortical degeneration, also called cerebellar abiotrophy, is a disease characterized by ataxia (lack of coordination), broad based stance, loss of balance, and intentional tremors. In different breeds of dogs, the onset is variable from neonatal to adult. In Beagles the condition is neonatal and onset is noticed at about 3 weeks of age as puppies begin to walk. The severity of the condition is variable among individuals but progression of clinical signs is minimal. Research identified an 8bp deletion in the Beta III Spectrin Gene (SPTBN2) associated with NCCD in Beagles.

NCCD is inherited as a recessive disease, thus both parents must carry the mutation in order to produce an affected puppy. Testing for NCCD in Beagles assists breeders to identify carriers and affected dogs.

 

Note: This test is specific for the 8bp deletion in the SPTBN2 associated with NCCD in Beagles.
Turnaround Time
3-6 business days

Species

Dog

Breed

Type of Test

Results Reported As
Test Result Neonatal Cerebellar Cortical Degeneration
N/N Normal. No copies of the NCCD mutation are present.
N/CCD Carrier. 1 copy of the NCCD mutation is present. Breedings between carriers are expected to produce 25% affected, 50% carrier, and 25% clear offspring.
CCD/CCD Affected. Animal has 2 copies of the NCCD mutation and is expected to have the disease.
References

Forman, O.P., De Risio, L., Stewart, J., Mellersh, C.S., & Beltran, E. (2012). Genome-wide mRNA sequencing of a single canine cerebellar cortical degeneration case leads to the identification of a disease associated SPTBN2 mutation. BMC Genetics, 13:55. doi: 10.1186/1471-2156-13-55