Congenital ichthyosis is a skin condition in which the outer layer of the skin does not form properly and results in scaling. The condition often progresses to large patches of thickened, black, scaly skin. Two genetic variants have been associated with congenital ichthyosis in the Golden Retriever.
The extent of shedding is impacted by several genes but two, MC5R and RSPO2, appear to have significant effect on the relative degree of shedding. Combinations of variants identified in these two genes result in decreased overall shedding rates.
Multidrug Sensitivity is caused by a deletion in the ABCB1 gene, also known as the multidrug resistance 1 (MDR1) gene, and is characterized by neurotoxicity following the use of certain common drugs.
Lhasa Apso Albinism (LAA) is an oculocutaneous albinism that is characterized by white or off-white fur and pink skin, and is caused by a missense variant in the SLC45A2 gene. This variant is also responsible for French Bulldog Pink.
Congenital myasthenic syndrome is a group of inherited neuromuscular disorders that are characterized by progressive muscle weakening that worsens with exercise.
Neuronal ceroid lipofuscinosis results from the accumulation of granules in the neurons of the brain and spinal cord. This progressive neurological disorder manifests as behavioral changes coupled with a loss of coordination and blindness.
Sensory ataxic neuropathy is a progressive neurological disorder characterized by involuntary muscle movements and abnormal posture resulting from degeneration of the nerves controlling muscle movement. It affects both sexes but is only inherited maternally.
In Doberman Pinschers, a neurological disorder causing deafness and balance/coordination issues, commonly referred to as DINGS, is associated with variants in two different genes. One appears to result in deafness in one ear while the other shows deafness in both ears.
