Pyruvate kinase deficiency in Labrador Retrievers is a chronic, severe hemolytic anemia caused by defective production of the enzyme pyruvate kinase. Signs in affected dogs may include lethargy, low exercise tolerance, and fatigue.
A mutation in the KIT gene has been found to be the source of the dominant white spotting pattern known as Panda that occurs in a line of German Shepherd Dogs.
A variant in the Keratin-71 gene is associated with curly hair in dogs. Dogs with this curl variant have curly coats or wavy coats depending on how many copies of the variant they possess.