Genetic Diversity Testing for Bernese Mountain Dogs

Overview

The Veterinary Genetics Laboratory (VGL), in collaboration with Dr. Niels C. Pedersen and staff, has developed a panel of short tandem repeat (STR) markers that will determine genetic heterogeneity and diversity across the genome and in the Dog Leukocyte Antigen (DLA) class I and II regions for specified dog populations. This test panel will be useful to dog breeders who wish to use DNA-based testing to track and increase genetic diversity as a supplement to in-depth pedigrees. DNA based information on genetic heterogeneity and diversity, along with DNA testing results for desired phenotypes and health traits, can aid in informing breeding decisions.

Genetic diversity testing of Bernese Mountain Dog is now in the preliminary results phase. During this phase, we continue to test more registered dogs to build genetic data necessary to provide breeders with an accurate assessment of genetic diversity. This report is based on testing of 41 registered Bernese Mountain Dogs from the USA and Canada. Although results reported herein are preliminary, this selection of individuals should provide a reasonable picture of genetic diversity within the breed. Allele and DLA haplotype frequencies will be updated as more dogs are tested. It is anticipated that new alleles at the 33 STR loci and additional DLA class I and II haplotypes will be identified in the future, but these will tend to be of much lower incidence than those detected in the present population.

Price

$80 one test per animal
 

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Turnaround Time

Please allow 5-10 business days for results.

Results reported as:

Short tandem repeat (STR) loci: A total of 33 STR loci from carefully selected regions of the genome were used to assess genetic heterogeneity and existing genetic diversity within an individual as well as across the breed. The alleles inherited from each parent are displayed graphically to highlight heterozygosity and genetic diversity in individuals and breed wide.

DLA haplotypes: Seven STR loci linked to the DLA class I and II genes were used to identify genetic differences in a region that regulates immune responses and self/non-self-recognition. Problems with self/non-self-recognition, along with non-genetic factors in the environment, are responsible for autoimmune disease, allergies, and susceptibility to infectious agents.

Internal Relatedness: The IR value is a measure of the genetic relatedness of an individual's parents. The value takes into consideration both heterozygosity of alleles at each STR loci and their relative frequency in the population. Therefore, IR values heterozygosity over homozygosity and uncommon alleles over common alleles. IR values are unique to each dog; two individuals from different sources may have identical IR values, but a quite different genetic makeup.

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