Genetic Diversity Testing for Shiba Inu

Overview

The Veterinary Genetics Laboratory (VGL), in collaboration with Dr. Niels C. Pedersen and staff, has developed a panel of 40 short tandem repeat (STR) markers that will determine genetic diversity across the genome and in the Dog Leukocyte Antigen (DLA) class I and II regions. This test panel will be useful to breeders who wish to track, rebalance or increase genetic diversity of their breed.

Genetic diversity testing of Shiba Inu is now in the preliminary results phase. During this phase, we will continue to test more registered dogs to provide breeders with an accurate assessment of genetic diversity in their breed. We are accepting Shiba Inu from all regions of the world. For this report we have tested 81 Shiba Inu originating from Japan and other countries, which should be adequate to determine 90% or more of existing genetic diversity. Additional dogs are tested the tables will be updated and genetic measurements re-calculated. The goal is to identify all existing diversity and to create a large DNA library for any future studies of Shiba Inu.

Price

$80 one test per animal
$70 when combined with a diagnostic test

ORDER TEST KITS

Turnaround Time

Allow 5-10 business days for results.

Results reported as:

Short tandem repeat (STR) loci: A total of 33 STR loci from across a representative portion of the genome were used to gauge genetic diversity within an individual and across the breed. The alleles inherited from each parent are displayed graphically to highlight heterozygosity, and breed-wide allele frequency is provided.

DLA haplotypes: Seven STR loci linked to the DLA class I and II genes were used to identify genetic differences in regions regulating immune responses and self/non-self-recognition. Problems with self/non-self-recognition, along with non-genetic factors in the environment, are responsible for autoimmune disease.

Internal Relatedness: The IR value is a measure of genetic diversity within an individual that takes into consideration both heterozygosity of alleles at each STR loci and their relative frequency in the population. Therefore, IR values heterozygosity over homozygosity and uncommon alleles over common alleles. IR values are unique to each dog and cannot be compared between dogs. Two dogs may have identical IR values but with very different genetic makeups.

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