UC Davis School of Veterinary Medicine Veterinary Genetics Laboratory
Genetic Diversity Testing for Polish Lowland Sheepdog

Overview

The Veterinary Genetics Laboratory (VGL), in collaboration with Dr. Niels C. Pedersen and staff, has developed a panel of short tandem repeat (STR) markers that will assess genetic diversity across the genome and in the Dog Leukocyte Antigen (DLA) class I and II regions. This test panel will be useful to breeders who wish to document and manage genetic diversity of their breed as a long-term goal.

This report is based on testing of 20 Polish Lowland Sheepdogs selected by breeders as representative of the breed. Although this number of dogs is probably insufficient in number or geographic location to do a definitive assessment of the breed, it should provide a reasonable picture of putative genetic diversity in the breed. Allele and DLA haplotype frequencies will be updated as more dogs are tested. It is anticipated that new alleles at the 33 STR loci and additional DLA class I and II haplotypes will be identified in the future, but these will tend to be of much lower incidence than those detected in the present population.

Price: $50.

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Results reported as:
Short tandem repeat (STR) loci: A total of 33 STR loci from carefully selected regions of the genome were used to gauge genetic diversity within an individual and across the breed. The alleles inherited from each parent are displayed graphically to highlight heterozygosity, and breed-wide allele frequency is provided.

DLA haplotypes: STR loci linked to the DLA class I and II genes were used to identify genetic differences in regions regulating immune responses and self/non-self recognition. Problems with self/non-self recognition, along with non-genetic factors in the environment, are responsible for autoimmune disease.

Internal Relatedness: The IR value is a measure of genetic diversity within an individual that takes into consideration both heterozygosity of alleles at each STR loci and their relative frequency in the population. Therefore, IR values heterozygosity over homozygosity and uncommon alleles over common alleles. IR values are unique to each dog and cannot be compared between dogs. Two dogs may have identical IR values but with very different genetic makeups.

Report

Report issued February 13, 2020. Daily updated statistics are here.

Veterinary Genetics Laboratory, Tel 530-752-2211, Email VGL