Albino

Quick Summary

The feline albino mutation is a rare mutation that produces a white coat with blue eyes, and is recessive to the sepia and Siamese mutations.

Phenotype: The albino mutation produces a white coat with blue eyes.

Mode of Inheritance: Autosomal recessive

Alleles: N = Normal/non-albino, A = Albino

Breeds appropriate for testing: Tonkinese, Siamese, blue-eyed white cats of other breeds

Explanation of Results:

  • Cats with N/N genoytpe will not be albino and cannot transmit this albino variant to their offspring.
  • Cats with A/N genotype will not be albino, but are carriers. They will transmit this albino variant to 50% of their offspring. Matings between two carriers are predicted to produce 25% albino kittens.
  • Cats with A/A genotype will be albino, and will transmit this albino variant to all of their offspring. Matings between two A/A genotype cats are predicted to produce all albino kittens.
Price

$40 one test per animal

Additional Details

Feline albinism is a rare inherited condition characterized by a lack of pigment resulting in cats with a white coat and blue eyes.

Two mutations in the Tyrosinase (TYR) gene produce the Burmese (sepia), Siamese, and mink colorpoint coat and eye color phenotypes in cats. A rare mutation in TYR (c.936delC) causes a shortened form of the TYR protein and produces an albino phenotype of a white coat with blue eyes. The albino mutation is recessive to the Burmese (cb) and Siamese(cs) mutations following the allelic series C>cb=cs>ca.

 

Note: The albino mutation is very rare in cats. Among 9229 cats tested by the VGL, only 4 (2 Tonkinese and 2 Siamese) were positive for this mutation. Because of its rarity, Albino has been removed from the coat color panel but will continue to be offered as a stand-alone test. If the genetic basis of a blue-eyed white cat is unknown to owners, we recommend first testing for Dominant White and White Spotting, before requesting the Albino test.
Turnaround Time
2-6 business days
Type of Sample

Species

Cat

Type of Test

Results Reported As
Test Result Albino
N/N No copies of albino allele are present.
A/N 1 copy of the albino allele is present.
A/A 2 copies of the albino allele are present. Cat is albino.
References

Imes, D. L., Geary, L. A., Grahn, R. A., & Lyons, L. A. (2006). Albinism in the domestic cat (Felis catus) is associated with a tyrosinase (TYR) mutation. Animal Genetics, 37(2), 175-178. doi: 10.1111/j.1365-2052.2005.01409.x