Health

Primary open-angle glaucoma (POAG) is a type of glaucoma that typically progresses gradually without obvious signs of pain. A genetic inversion disrupting the ADAMTS17 gene is associated with POAG in the Petit Basset Griffon Vendeen, which is characterized by elevated intraocular pressure and lens subluxation, and can lead to vision loss at a later stage of the disease.

GM2 gangliosidosis is a fatal neurodegenerative lysosomal storage disease that affects dogs. This GM2 gangliosidosis allele has been identified in Toy Poodles.

Cerebellar Degeneration-Myositis Complex (CDMC) is a heritable disorder that causes neurological signs that manifest as early as 10 weeks of age in affected Nova Scotia Duck Tolling Retrievers.

Cardiac Laminopathy (CLAM) is a fatal heritable condition that results in dilated cardiomyopathy and sudden death in young adult Nova Scotia Duck Tolling Retrievers

Progressive retinal atrophy rod-cone degeneration 4 (rcd4-PRA) is a heritable condition characterized by late-onset degeneration of photoreceptor cells in the retina, leading to loss of vision and blindness.

Congenital ichthyosis is a skin condition in which the outer layer of the skin does not form properly and results in scaling. The condition often progresses to large patches of thickened, black, scaly skin. Two genetic variants have been associated with congenital ichthyosis in the Golden Retriever.

Multidrug Sensitivity is caused by a deletion in the ABCB1 gene, also known as the multidrug resistance 1 (MDR1) gene, and is characterized by neurotoxicity following the use of certain common drugs.

Foal Immunodeficiency Syndrome (FIS) is an inherited, fatal immunodeficiency found in the Fell and Dales Pony Breeds. This syndrome is characterized by profound anemia and chronic infections.