GM1 gangliosidosis in the Shiba Inu breed (SI-GM1) is a progressive, lethal disorder caused by abnormal accumulation of a fatty molecule important for normal functioning of nerve cells in the brain.
Autosomal recessive amelogenesis imperfecta (ARAI), also known as familial enamel hypoplasia (FEH), is an inherited genetic disorder of tooth enamel that occurs in Samoyeds.
Necrotizing meningoencephalitis (NME), also known as Pug dog encephalitis, is an inflammatory disease of the central nervous system that is usually progressive and fatal. Several genetic markers are associated with risk of developing NME.
Addison’s disease occurs when the adrenal glands stop secreting necessary natural steroid hormones. In the Nova Scotia Duck Tolling Retriever, a genetic form of Addison's disease can occur in puppies.
There are multiple genetic causes of cleft palate within the Nova Scotia Duck Tolling Retriever breed. The most common form has been identified as CP1.
The CLPS genetic variant causes development of cleft palate and/or cleft lip, sometimes also accompanied by syndactly (fused toes), in Nova Scotia Duck Tolling Retriever puppies.