Genetic Diversity Testing for Giant Schnauzers

Overview

The Veterinary Genetics Laboratory (VGL), in collaboration with Dr. Niels C. Pedersen and staff, has developed a panel of short tandem repeat (STR) markers that will determine genetic diversity across most of the genome and in the Dog Leukocyte Antigen (DLA) class I and II regions. This test panel will be useful to breeders who wish to track and increase genetic diversity of their breed as a long-term goal.

Genetic diversity testing of Giant Schnauzer is now in the data collection phase. During this phase, we will continue to test more registered dogs to build genetic data necessary to provide breeders with an accurate assessment of genetic diversity in their breed. We are accepting dogs from the USA and Canada, as well as from other regions of the world. At the time of writing the report below we had tested 133 Giant Schnauzers – 106 from the US and Canada, and 27 from Europe (mainly UK). Although this number of dogs will probably cover 95% or more of the genetic diversity that exists in dogs from North America, the report will be updated when no new genomic alleles or DLA haplotypes are being recognized.

Price

$80 one test per animal
$70 when combined with a diagnostic test

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Turnaround Time

Allow 5-10 business days for results.

Results reported as:

Short tandem repeat (STR) loci: A total of 33 STR loci from across the genome were used to gauge genetic diversity within an individual and across the breed. The alleles inherited from each parent are displayed graphically to highlight heterozygosity, and breed-wide allele frequency is provided.

DLA haplotypes: STR loci linked to the DLA class I and II genes were used to identify genetic differences in regions regulating immune responses and self/non-self-recognition. Problems with self/non-self-recognition, along with non-genetic factors in the environment, are responsible for autoimmune disease, allergies, and immunodeficiency.

Internal Relatedness: The IR value is a measure of genetic diversity within an individual that takes into consideration both heterozygosity of alleles at each STR loci and their relative frequency in the population. It is also an estimate of the genetic relatedness of a dog’s parents. Unlike standard genetic assessments, IR puts more emphasis on heterozygosity over homozygosity and uncommon over common alleles. IR values are unique to each dog and cannot be compared between dogs. Two dogs may have identical IR values but with very different genetic makeups

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