Discovered at UC Davis Cardiac Laminopathy (CLAM) in the Nova Scotia Duck Tolling Retriever

Quick Summary

Cardiac Laminopathy (CLAM) is a fatal heritable condition that results in dilated cardiomyopathy and sudden death in young adult Nova Scotia Duck Tolling Retrievers

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Phenotype: Affected dogs present with dilated cardiomyopathy at a young age and typically experience sudden death within the first year of age.

Mode of Inheritance: Autosomal recessive

Alleles: N = Normal, CLAM = Cardiac Laminopathy

Breeds appropriate for testing: Nova Scotia Duck Tolling Retriever

Explanation of results:

•   Dogs with N/N genotype are expected to not have cardiac laminopathy. They cannot transmit this CLAM variant to any of their offspring.

•   Dogs with N/CLAM genotype are carriers of cardiac laminopathy. They will transmit this CLAM variant to 50% of their offspring. Matings between two carriers of CLAM may, on average, produce 25% of puppies with cardiac laminopathy.

•   Dogs with CLAM/CLAM genotypes are homozygous for the CLAM variant and will have cardiac laminopathy which is ultimately a fatal condition.

Price

$50 one test per animal
$30 as additional test (same animal)

Turnaround Time
at least 15 business days; may be delayed beyond 15 business days if sample requires additional testing, or a new sample is requested.
Additional Details

Cardiac Laminopathy (CLAM) is caused by a deletion in a single gene. The condition appears to be inherited in an autosomal recessive manner, meaning that two copies of the CLAM variant are needed for the disease to be expressed. Affected dogs are homozygous for the variant and present with sudden death associated with dilated cardiomyopathy. No treatment is available at this time and the condition is typically lethal in young adult dogs. Affected dogs studied to date experienced sudden death by 1.5 years of age.  This research is not yet published, however the genetic variant causing this disease was recently discovered by Dr. Bannasch here at UC Davis in the School of Veterinary Medicine and she has shared this finding with the VGL pre-publication so that we can more rapidly offer genetic testing to toller breeders as soon as discoveries are made. The VGL will update this website when more information is available.

Testing recommendations: DNA testing for cardiac laminopathy can determine the genetic status of dogs. Dogs with one copy of the CLAM variant are normal but are carriers. Matings between two carrier dogs may, on average, produce 25% of puppies with cardiac laminopathy, which is a lethal condition in young adult dogs.

Species

Dog

Type of Test

Results Reported As

Test Result

Cardiac Laminopathy (CLAM)

N/N

Normal. No copies of the Nova Scotia Duck Tolling Retriever cardiac laminopathy (CLAM) allele detected.

N/CLAM

Carrier. One copy of the Nova Scotia Duck Tolling Retriever cardiac laminopathy (CLAM) allele detected.

CLAM/CLAM

Affected. Two copies of the Nova Scotia Duck Tolling Retriever cardiac laminopathy (CLAM) allele detected.  Dog will likely develop the disease.

References

Coming soon!