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Phenotype: Affected dogs present with dilated cardiomyopathy at a young age and typically experience sudden death within the first year of age.
Mode of Inheritance: Autosomal recessive
Alleles: N = Normal, CLAM = Cardiac Laminopathy
Breeds appropriate for testing: Nova Scotia Duck Tolling Retriever
Explanation of results:
• Dogs with N/N genotype are expected to not have cardiac laminopathy. They cannot transmit this CLAM variant to any of their offspring.
• Dogs with N/CLAM genotype are carriers of cardiac laminopathy. They will transmit this CLAM variant to 50% of their offspring. Matings between two carriers of CLAM may, on average, produce 25% of puppies with cardiac laminopathy.
• Dogs with CLAM/CLAM genotypes are homozygous for the CLAM variant and will have cardiac laminopathy which is ultimately a fatal condition.