Renal Cystadenocarcinoma and Nodular Dermatofibrosis (RCND) of German Shepherd Dogs

Quick Summary

Renal cystadenocarcinoma and nodular dermatofibrosis is an inherited cancer in German Shepherd Dogs.

Phenotype: The disease has late onset and is progressive. Affected animals develop multiple firm nodules (dermatofibrosis) in the skin typically by 6 years of age. They also develop bilateral, multifocal tumors (cystadenocarcinoma) in the kidney, although the timing and rate of growth is varied.

Mode of Inheritance: Autosomal dominant

Alleles: N = Normal, RCND = Renal cystadenocarcinoma and nodular dermatofibrosis

Breeds appropriate for testing: German Shepherd Dog

Explanation of Results:

  • Dogs with N/N genotype will not have renal cystadenocarcinoma and nodular dermatofibrosis (RCND) and cannot transmit this variant to their offspring.
  • Dogs with N/RCND genotype will have RCND. They may transmit this variant to 50% of their offspring. If bred to a N/N dog, 50% of offspring are predicted to be normal and 50% are predicted to have RCND. If bred to a N/RCND dog, only 25% of the offspring are predicted to be normal (no copies of the variant).
  • Dogs with RCND/RCND genotype will have RCND and may not be viable (no RCND/RCND living dogs yet identified).
Price

$50 one test per animal
$30 as additional test (same animal)

Panels Available
Additional Details

Renal cystadenocarcinoma and nodular dermatofibrosis (RCND) is an inherited cancer in German Shepherd Dogs. The disease has late onset and is progressive. Affected animals develop multiple firm nodules (dermatofibrosis) in the skin typically by 6 years of age. They also develop bilateral, multifocal tumors (cystadenocarcinoma) in the kidney, although the timing and rate of growth is varied.

RCND in the German Shepherd Dog breed results from a mutation in exon 7 (c.764A>G) of the folliculin (FLCN) gene. The disease is inherited in an autosomal dominant fashion, which means that males and females are equally affected and that a single copy of the defective gene will cause disease. Animals with two defective copies have not been identified, suggesting this genotype is incompatible with life.

Testing for RCND assists veterinarians with diagnosis of RNCD and helps breeders identify affected dogs among breeding stock to avoid producing affected puppies. Matings between two dogs that have one copy each of the RCND mutation are expected to produce only 25% of normal puppies with no copies of the mutation. This mating may also result in potential loss of embryos with two copies of the RCND mutation as it appears to be homozygous lethal.

Turnaround Time
5-10 business days

Species

Dog

Type of Test

Results Reported As
Test Result Renal Cystadenocarcinoma and Nodular Dermatofibrosis

N/N

Normal. No copies of the RCND mutation.

N/RCND

Affected. 1 copy of the RCND mutation.

RCND/RCND

Affected. 2 copies of the RCND mutation (may not be viable).

References

Lingaas, F., Comstock, K.E., Kirkness, E.F., Sørensen, A., Aarskaug, T., Hitte, C., Nickerson, M.L., Moe, L., Schmidt, L.S., Thomas, R., Breen, M., Galibert, F., Zbar, B., & Ostrander, E.A. (2003). A mutation in the canine BHD gene is associated with hereditary multifocal renal cystadenocarcinoma and nodular dermatofibrosis in the German Shepherd dog. Human Molecular Genetics, 12(23), 3043-3053. doi: 10.1093/hmg/ddg336