Koolie

Dilute (D Locus/Blue)

Several gene variants are known to produce dilute coloration in dogs. Colors are lightened (diluted) to paler shades as a result of the variants' effects on pigmentation.

MC1R including Mask, Grizzle, and Red/Cream (E Locus)

The melanocortin 1 receptor (MC1R) gene controls production of the pigments eumelanin (black) and phaeomelanin (red/yellow). Six known variants of this gene are responsible for producing markings and coat colors including melanistic mask, grizzle/domino, black, and shades of red/yellow.

Hyperuricosuria (HUU)

Hyperuricosuria is an inherited disorder characterized by elevated levels of uric acid in the urine that can lead to the formation of bladder/kidney stones.

Degenerative Myelopathy (DM)

Degenerative myelopathy (DM) is an inherited neurologic disorder of dogs characterized by gradual muscle wasting and loss of coordination typically beginning in the hind limbs. Testing is most appropriate for those breeds in which the clinical disease has been associated with the SOD1 allele.

Canine Multifocal Retinopathy 1 (CMR1)

Canine multifocal retinopathy 1 is an inherited eye disease characterized by areas of retinal detachment. The disease does not typically lead to blindness or vision deficits.