Factor VII Deficiency

Quick Summary

Factor VII deficiency is a mild to moderate inherited blood clotting disorder. Affected dogs may appear mostly healthy but may be prone to increased bleeding tendency.

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Phenotype: Affected dogs may appear mostly healthy but may be prone to increased bleeding tendency.

Mode of Inheritance: Autosomal recessive

Alleles: N = Normal, FVII = Factor VII deficiency

Breeds appropriate for testing: Beagle, Airedale, Alaskan Klee Kai, American Foxhound, Finnish Hound, German Wirehaired Pointer, Giant Schnauzer, Irish Water Spaniel, Japanese Spitz, Miniature Schnauzer, Papillon/Phalene, Sealyham Terrier, Scottish Deerhound, Welsh Springer Spaniel

Explanation of Results:

  • Dogs with N/N genotype will not have factor VII deficiency and cannot transmit this FVII variant to their offspring.
  • Dogs with N/FVII genotype will not have factor VII deficiency, but are carriers. They will transmit this FVII variant to 50% of their offspring. Matings between two carriers are predicted to produce 25% factor VII deficiency-affected puppies.
  • Dogs with FVII/FVII genotype will have factor VII deficiency, a mild to moderate blood clotting disorder, and will transmit this FVII variant to all of their offspring.

Results of this test can be submitted to the OFA (Orthopedic Foundation for Animals)

Turnaround Time
At least 15 business days; may be delayed beyond 15 business days if sample requires additional testing, or a new sample is requested.
Price

$55 single test per animal ($5 discount on 3 or more dogs)
$25 as additional health test on same animal

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Additional Details

Factor VII is a clotting factor synthesized in the liver that is necessary to initiate blood coagulation when vascular injury occurs. Factor VII deficiency is a mild to moderate inherited blood clotting disorder present in Beagles and several other dog breeds (see "Breeds appropriate for testing" list above). It is inherited as an autosomal recessive, thus both females and males can be affected if they carry 2 copies of the defective gene; individuals with only 1 copy of the mutation are not affected.

Type of Sample
Cytology Brush - supplied by VGL at no additional charge (PREFERRED)
Mini mascara brushes - supplied by owner (click for accepted type)
Interdental/GUM brushes - supplied by owner (click for accepted types)

Species

Dog

Breed

Airedale Terrier Alaskan Klee Kai American Foxhound Beagle Finnish Hound German Wirehaired Pointer Giant Schnauzer Irish Water Spaniel Japanese Spitz Papillon Phalene Schnauzer, Miniature Scottish Deerhound Sealyham Terrier Welsh Springer Spaniel
Type of Test
Health
Results Reported As
Test Result Factor VII deficiency
N/N Normal. No copies of the Factor VII deficiency mutation are present.
N/FVII Carrier. 1 copy of the Factor VII deficiency mutation is present. If carriers are bred together, 25% of offspring are expected to be affected.
FVII/FVII Affected.
References

Callan, M.B., Aljamali, M.N., Margaritis, P., Griot-Wenk, M.E., Pollak, E.S., Werner, P., Giger, U. & High, K.A. (2006). A novel missense mutation responsible for factor VII deficiency in research Beagle colonies. Journal of Thrombosis and Haemostasis, 4, 2616–2622. doi: 10.1111/j.1538-7836.2006.02203.x

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