Familial Enamel Hypoplasia (FEH) of Italian Greyhounds

Quick Summary

Autosomal recessive amelogenesis imperfecta (ARAI), also known as familial enamel hypoplasia (FEH), is an inherited genetic disorder of tooth enamel that occurs in Italian Greyhounds.

Closeup of Italian Greyhound teeth, affected by FEH.
Italian Greyhound with FEH. The enamel surfaces are roughened, with blochy discoloration. Cavities are uncommon, but this dog has cavities at tips of upper and lower canines.
Closeup of Italian Greyhound teeth, unaffected by FEH
Italian Greyhound with normal teeth. Teeth are larger, not pointed; enamel is smooth, not discolored. Gaps between teeth are narrower.

Phenotype: Familial enamel hypoplasia (FEH) is characterized by enamel pitting and tooth discoloration; often teeth are unusually small, pointed, and prone to increasing gaps between teeth with age.

Mode of Inheritance: Autosomal recessive

Alleles: N = Normal, FEH = Familial enamel hypoplasia

Breeds appropriate for testing: Italian Greyhound

Explanation of Results:

  • Dogs with N/N genotype will not have familial enamel hypoplasia and cannot transmit this variant to their offspring.
  • Dogs with N/FEH genotype will not be affected by familial enamel hypoplasia, but are carriers. They will transmit this variant to 50% of their offspring. Matings between two carriers are predicted to produce 25% familial enamel hypoplasia-affected puppies.
  • Dogs with FEH/FEH genotype will have familial enamel hypoplasia and will transmit this variant to all of their offspring.

Results of this test can be submitted to the OFA (Orthopedic Foundation for Animals)

Price

$50 one test per animal
$30 as additional test (same animal)

Panels Available
Additional Details

Autosomal recessive amelogenesis imperfecta (ARAI) is an inherited genetic disorder of tooth enamel that occurs in Italian Greyhounds. It is commonly known to breeders as familial enamel hypoplasia (FEH). It is characterized by enamel pitting and tooth discoloration; often teeth are unusually small, pointed and prone to increasing gaps between teeth with age. There appears to be no association of FEH with periodontitis.

Dr. Niels Pedersen and his research group at the School of Veterinary Medicine, University of California, Davis identified the mutation associated with FEH in Italian Greyhounds. It is estimated that 14% of Italian Greyhounds are affected with FEH and 30% are carriers.

Testing for FEH assists owners and breeders in identifying affected and carrier dogs. Breeders can use results from the test as a tool for selection of mating pairs to avoid producing affected dogs.

 

Note: This test is only for the variant associated with FEH in Italian Greyhounds. If you would like to test a Samoyed for FEH, see the breed-specific Samoyed test.
Turnaround Time
3-6 business days

Species

Dog

Type of Test

Results Reported As
Test Result Familial Enamel Hypoplasia
N/N No copies of FEH mutation. Dog is normal.
N/FEH 1 copy of FEH mutation. Dog is normal but is a carrier.
FEH/FEH 2 copies of FEH mutation. Dog is affected.
References

Gandolfi, B., Liu, H., Griffioen, L., & Pedersen, N.C. (2013). Simple recessive mutation in ENAM is associated with amelogenesis imperfecta in Italian Greyhounds. Animal Genetics, 44(5), 569-578. doi: 10.1111/age.12043