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Phenotype: Osteochondrodysplasia is characterized by stunted growth and abnormal locomotion. Affected animals develop splayed hind limbs, enlarged joints, flattened rib cages, shortened and bent long bones, and deformed paws.
Mode of Inheritance: Autosomal recessive
Alleles: N = Normal, OCD = Osteochondrodysplasia
Breeds appropriate for testing: Miniature Poodle
Explanation of Results:
- Dogs with N/N genotype will not have osteochondrodysplasia and cannot transmit this osteochondrodysplasia variant to their offspring.
- Dogs with N/OCD genotype will not have osteochondrodysplasia, but are carriers. They may transmit this osteochondrodysplasia variant to 50% of their offspring. Matings between two carriers are predicted to produce 25% osteochondrodysplasia-affected puppies.
- Dogs with OCD/OCD genotype will have osteochondrodysplasia, an inherited skeletal and cartilaginous disorder.
Results of this test can be submitted to the OFA (Orthopedic Foundation for Animals)
Osteochondrodysplasia (OCD) is an inherited disorder found in Miniature Poodles. The disease is characterized by stunted growth and abnormal locomotion that can be observed at about 3 weeks of age. Affected animals develop abducted (splayed) hind limbs, enlarged joints, flattened rib cages, shortened and bent long bones and deformed paws. The inheritance is autosomal recessive, thus both sexes are equally affected and carriers show no signs of the disease. Research has identified a deletion in the Sulfate Transporter gene, SLC13A1, which is associated with OCD in Miniature Poodles.
Type of Test
|N/N||Normal. No copies of OCD deletion are present.|
Carrier. 1 copy of OCD deletion is present. If carriers are bred together, 25% of offspring are expected to be affected.
|OCD/OCD||Affected. 2 copies of OCD deletion are present.|
Neff, M.W., Beck, J.S., Koeman, J.M., Boguslawski, E., Kefene, L., Borgman, A., & Ruhe, A.L. (2012). Partial deletion of the Sulfate Transporter SLC13A1 is associated with an osteochondrodysplasia in the Miniature Poodle breed. PLoS ONE 7(12): e51917. doi: 10.1371/journal.pone.0051917