Loss of cone function due to cone degeneration results in day-blindness and decreased visual acuity. There are 2 known mutations of the CNGB3 gene that cause canine cone degeneration day-blindness in dogs.
Osteochondrodysplasia is characterized by stunted growth and abnormal locomotion. Affected animals develop splayed hind limbs, enlarged joints, flattened rib cages, shortened and bent long bones, and deformed paws.
Hyperuricosuria is an inherited disorder characterized by elevated levels of uric acid in the urine that can lead to the formation of bladder/kidney stones.
Von Willebrand disease III (vWD Type 3), an inherited bleeding disorder, results from a lack or reduced level of a normal blood clotting protein and is characterized by spontaneous hemorrhaging and prolonged bleeding after physical trauma. vWD Type 3 is the most severe form.
Von Willebrand disease II (vWD Type 2), an inherited bleeding disorder, results from a lack or reduced level of a normal blood clotting protein and is characterized by spontaneous hemorrhaging and prolonged bleeding after physical trauma. vWD Type 2 is rare.
Previously described as juvenile-onset, laryngeal paralysis and polyneuropathy (JLPP), polyneuropathy with ocular abnormalities and neuronal vacuolation (POANV) is a progressive, fatal neurological disorder seen in Black Russian Terriers and Rottweilers.
Primary lens luxation is a painful inherited eye disorder where the lens of the eye moves from its normal position, causing inflammation and glaucoma. If untreated, the condition can rapidly lead to blindness.
Neonatal encephalopathy with seizures is an inherited progressive brain disease of Standard Poodles and related crosses that is characterized by weakness, mobility issues, and seizures. Affected pups do not survive beyond seven weeks of age.
Mucopolysaccharidosis VII (MPS VII) is a lysosomal storage disease characterized by skeletal abnormalities, retarded development, excessively lax joints, and difficulty standing and walking.
