Phenotype: Hyperuricosuria is characterized by elevated levels of uric acid in the urine and can lead to the formation of bladder/kidney stones.
Mode of Inheritance: Autosomal recessive
Alleles: N = Normal/Unaffected, HU = Hyperuricosuria
Breeds appropriate for testing: All dog breeds, including American Pitbull Terrier, American Staffordshire Terrier, Australian Shepherd, Black Russian Terrier, Bulldog, Catahoula Leopard Dog, Dalmatian, Danish-Swedish Farmdog, French Bulldog, German Hunting Terrier, German Shepherd, Giant Schnauzer, Jack Russel/Parsons Terrier, Kromfohrländer, Labrador Retriever, Lagotto Romagnolo, Large Munsterlander, South African Boerboel, Spaniel de Pont-Audemer, Swedish Vallhund, Vizsla, Weimaraner
Explanation of Results:
- Dogs with N/N genotype will not have hyperuricosuria and will not transmit this hyperuricosuria variant to their offspring.
- Dogs with N/HU genotype will not have hyperuricosuria, but are carriers. They will transmit this variant to 50% of their offspring. Matings between two carriers are predicted to produce 25% hyperuricosuria-affected puppies.
- Dogs with HU/HU genotype will be affected and are susceptible to develop bladder/kidney stones. They will transmit this hyperuricosuria variant to all of their offspring.
Results of this test can be submitted to the OFA (Orthopedic Foundation for Animals)