Multiple congenital ocular anomalies (MCOA) is an inherited eye disorder that is associated with the silver dilution and is characterized by ocular cysts, enlargement of the cornea, abnormally formed iris/retina, and additional abnormalities.
Pre-implantation genetic diagnosis (PGD) is a procedure used to screen embryos recovered after uterine flush to determine sex and genetic traits through DNA testing prior to implantation in the uterus.
The silver dilution dilutes black/brown pigment to lighten the manes and tails of black and bay horses to a flaxen or silver gray. The silver dilution is also associated with an inherited ocular syndrome known as Multiple Congenital Ocular Anomalies (MCOA).
Dominant white is a variable white spotting pattern caused by many different mutations in the KIT gene. The VGL tests for the four most common mutations known as W5, W10, W20, and W22. Homozygosity for W5, W10, or W22 is thought to be non-viable.