Leukoencephalomyelopathy (LEMP) in Rottweilers and Great Danes

Quick Summary

Leukoencephalomyelopathy is a neurodegenerative disorder of the central nervous system characterized by a generalized, progressive loss of balance with increasing immobility.

Phenotype: Leukoencephalomyelopathy (LEMP) is characterized by a generalized, progressive loss of balance with increasing immobility. Signs of LEMP often appear prior to 1 year of age, typically presenting as gait abnormalities including dragging of paws and knuckling.

Mode of Inheritance: Autosomal recessive

Alleles: N = Normal, LEMP = Leukoencephalomyelopathy

Breeds appropriate for testing: Rottweiler, Great Dane

Explanation of Results:

  • Dogs with N/N genotype will not have leukoencephalomyelopathy and cannot transmit this leukoencephalomyelopathy variant to their offspring.
  • Dogs with N/LEMP genotype will not have leukoencephalomyelopathy, but are carriers. They will transmit this LEMP variant to 50% of their offspring. Matings between two carriers are predicted to produce 25% leukoencephalomyelopathy-affected puppies.
  • Dogs with LEMP/LEMP genotype will have leukoencephalomyelopathy, a progressive neurodegenerative disorder.

Results of this test can be submitted to the OFA (Orthopedic Foundation for Animals)

Price

$50 one test per animal
$30 as additional test (same animal)
$45 for 3 or more dogs

Panels Available
Additional Details

Leukoencephalomyelopathy (LEMP) is a neurodegenerative disorder of the central nervous system. LEMP is characterized by a generalized, progressive loss of balance with increasing immobility. Signs of LEMP often appear prior to 1 year of age, typically presenting as gait abnormalities including dragging of paws and knuckling. The disease is progressive, moving from front to back limbs but is not associated with pain.

LEMP in Rottweiler dogs results from an insertion of one base in the NAPEPLD gene (c.345_346insC), reported here as LEMP. The disease is inherited in an autosomal recessive fashion, which means that males and females are equally affected and that two copies of the defective gene are needed to cause LEMP. Dogs with one normal and one affected gene (carriers) are normal and show no signs of the disease. This variant is also present in Great Danes, therefore testing for this breed is advisable.

Testing for the mutation associated with LEMP in Rottweiler and Great Dane breeds assists clinicians with diagnosis of LEMP and helps breeders identify carriers among breeding stock to avoid producing affected dogs. Matings between carriers are expected to produce 25% of affected puppies.

 

Note: This test does not identify the variant responsible for LEMP in Leonbergers.
Turnaround Time
5-10 business days

Species

Dog

Type of Test

Results Reported As
Test Result Leukoencephalomyelopathy (LEMP)

N/N

Normal. No copies of the LEMP mutation.

N/LEMP

Carrier. 1 copy of the LEMP mutation.

LEMP/LEMP

Affected. 2 copies of the LEMP mutation.

References

Minor, K.M., Letko, A., Becker, D., Drögemüller, M., Mandigers, P.J., Bellekom, S., Leegwater, P.A., Stassen, Q.E., Putschbach, K., Fischer, A., Flegel, T., Matiasek, K., Ekenstedt, K.J., Furrow, E., Patterson, E.E., Platt, S., Kelly, P., Cassidy, J.P., Shelton, G.D., Lucot, K., Bannasch, D.L., Martineau, H.M., Muir, C.F., Priestnall, S.L., Henke, D., Oevermann, A., Jagannathan, V., Mickelson, J.R., & Drögemüller, C. (2018). Canine NAPEPLD-associated models of human myelin disorders. Scientific Reports, 8,5818. doi: 10.1038/s41598-018-23938-7