Collie Eye Anomaly (CEA), also known as choroidal hypoplasia, is a heritable disorder that can result in abnormal development of inner structures of the eye. This genetic variant is associated with CEA in multiple breeds.
Cardiac Laminopathy (CLAM) is a fatal heritable condition that results in dilated cardiomyopathy and sudden death in young adult Nova Scotia Duck Tolling Retrievers
Cerebellar Degeneration-Myositis Complex (CDMC) is a heritable disorder that causes neurological signs that manifest as early as 10 weeks of age in affected Nova Scotia Duck Tolling Retrievers.
Chondrodystrophy, a trait that is characterized by a short-legged phenotype, also impacts the health of dogs. Dogs with at least one copy of the mutation have premature disc degeneration and increased susceptibility to disc herniation.
The CLPS genetic variant causes development of cleft palate and/or cleft lip, sometimes also accompanied by syndactly (fused toes), in Nova Scotia Duck Tolling Retriever puppies.
There are multiple genetic causes of cleft palate within the Nova Scotia Duck Tolling Retriever breed. The most common form has been identified as CP1.
Collie Eye Anomaly (CEA), also known as choroidal hypoplasia, is a heritable disorder that can result in abnormal development of inner structures of the eye. This genetic variant is associated with CEA in multiple breeds.
Two variants in the Keratin-71 gene are associated with curly hair in dogs. Dogs with these curl variants have curly coats or wavy coats depending on how many copies of the allele they possess.
Degenerative myelopathy (DM) is an inherited neurologic disorder of dogs characterized by gradual muscle wasting and loss of coordination typically beginning in the hind limbs. Testing is most appropriate for those breeds in which the clinical disease has been associated with the SOD1 allele.
Several gene variants are known to produce dilute coloration in dogs. Colors are lightened (diluted) to paler shades as a result of the variants' effects on pigmentation.
The Dominant Black gene (K Locus) affects pigment switching between eumelanin (black) and phaeomelanin (red or yellow) by interacting with the Agouti and MC1R genes.
Hyperuricosuria is an inherited disorder characterized by elevated levels of uric acid in the urine that can lead to the formation of bladder/kidney stones.
Addison’s disease occurs when the adrenal glands stop secreting necessary natural steroid hormones. In the Nova Scotia Duck Tolling Retriever, a genetic form of Addison's disease can occur in puppies.
The melanocortin 1 receptor (MC1R) gene controls production of the pigments eumelanin (black) and phaeomelanin (red/yellow). Six known variants of this gene are responsible for producing markings and coat colors including melanistic mask, grizzle/domino, black, and shades of red/yellow.
White spotting patterns that occur in many dog breeds do not have a uniform genetic basis, and the genetics are complex. In piebald/parti/random white spotting, the extent of white pattern expression varies, and markings are often asymmetrical.
Progressive rod-cone degeneration (PRCD) is an inherited form of late-onset progressive retinal atrophy (PRA) that has been identified in many dog breeds.
