Labrador Retriever

The Brown gene dilutes eumelanin (black pigment) to brown but does not affect phaeomelanin (red/yellow pigment).

The melanocortin 1 receptor (MC1R) gene controls production of the pigments eumelanin (black) and phaeomelanin (red/yellow). Six known variants of this gene are responsible for producing markings and coat colors including melanistic mask, grizzle/domino, black, and shades of red/yellow.

Centronuclear myopathy is a hereditary myopathy of Labrador Retrievers characterized by generalized loss of muscle tone and control.

Narcolepsy in Labrador Retrievers is a sleeping disorder characterized by daytime sleepiness, fragmented sleep patterns, and sudden transient episodes of muscle weakness or paralysis triggered by play or food. This test detects a causal variant specific to Labrador Retrievers.

Congenital myasthenic syndrome (CMS) is a neuromuscular disorder in Labrador Retrievers characterized by generalized muscle weakness and fatigue, often induced by exercise.

Progressive retinal atrophy (PRA) is characterized by bilateral degeneration of the retina resulting in progressive vision loss leading to total blindness. More than one form of PRA affects Golden Retrievers, and causal mutations in three distinct genes have been identified; two of those mutations lead to PRA1 and PRA2.

Hyperuricosuria is an inherited disorder characterized by elevated levels of uric acid in the urine that can lead to the formation of bladder/kidney stones.

Hereditary nasal parakeratosis is an inherited, recessive genetic defect that affects specialized cells of the canine nose, resulting in the formation of a crust with cracks over the nasal area of young dogs.

Exercise-induced collapse is a genetic neuromuscular disorder characterized by muscle weakness, lack of coordination, and life-threatening collapse after intense exercise in otherwise apparently healthy dogs.