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Phenotype: Exercise-induced collapse (EIC) is characterized by muscle weakness, lack of coordination, and life-threatening collapse after intense exercise in otherwise apparently healthy dogs. Affected dogs tolerate mild to moderate activity but will display signs of EIC after 5-20 minutes of strenuous exercise. The severity of EIC varies. EIC episodes last from 5-25 minutes with a gradual return to normal with no apparent residual weakness or stiffness.
Mode of Inheritance: Autosomal recessive
Alleles: N = Normal, EIC = Exercise-induced collapse
Breeds appropriate for testing: Australian Cobberdog, Australian Labradoodle, Bouvier des Flandres, Boykin Spaniel, Cardigan Welsh Corgi, Chesapeake Bay Retriever, Cockapoo, Cocker Spaniel, Clumber Spaniel, Curly Coated Retriever, Deutsch-Drahthaar, English Cocker Spaniel, German Wirehaired Pointer, Labrador crosses, Labradoodle, Labrador Retriever, Old English Sheepdog, Pembroke Welsh Corgi, Vizsla
Explanation of Results:
- Dogs with N/N genotype will not have exercise-induced collapse and cannot transmit this EIC variant to their offspring.
- Dogs with N/EIC genotype will not have exercise-induced collapse, but are carriers. They will transmit this EIC variant to 50% of their offspring. Matings between two carriers are predicted to produce 25% exercise-induced collapse-affected puppies.
- Dogs with EIC/EIC genotype will be prone to exercise-induced collapse, a serious but usually manageable neuromuscular disorder.
Results of this test can be submitted to the OFA (Orthopedic Foundation for Animals)