Exercise-Induced Collapse (EIC)

Quick Summary

Exercise-induced collapse is a genetic neuromuscular disorder characterized by muscle weakness, lack of coordination, and life-threatening collapse after intense exercise in otherwise apparently healthy dogs.
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Phenotype: Exercise-induced collapse (EIC) is characterized by muscle weakness, lack of coordination, and life-threatening collapse after intense exercise in otherwise apparently healthy dogs. Affected dogs tolerate mild to moderate activity but will display signs of EIC after 5-20 minutes of strenuous exercise. The severity of EIC varies. EIC episodes last from 5-25 minutes with a gradual return to normal with no apparent residual weakness or stiffness.

Mode of Inheritance: Autosomal recessive

Alleles: N = Normal, EIC = Exercise-induced collapse

Breeds appropriate for testing: Australian Cobberdog, Australian Labradoodle, Bouvier des Flandres, Boykin Spaniel, Cardigan Welsh Corgi, Chesapeake Bay Retriever, Cockapoo, Cocker Spaniel, Clumber Spaniel, Curly Coated Retriever, Deutsch-Drahthaar, English Cocker Spaniel, German Wirehaired Pointer, Labrador crosses, Labradoodle, Labrador Retriever, Old English Sheepdog, Pembroke Welsh Corgi, Vizsla

Explanation of Results:

  • Dogs with N/N genotype will not have exercise-induced collapse and cannot transmit this EIC variant to their offspring.
  • Dogs with N/EIC genotype will not have exercise-induced collapse, but are carriers. They will transmit this EIC variant to 50% of their offspring. Matings between two carriers are predicted to produce 25% exercise-induced collapse-affected puppies.
  • Dogs with EIC/EIC genotype will be prone to exercise-induced collapse, a serious but usually manageable neuromuscular disorder.

Results of this test can be submitted to the OFA (Orthopedic Foundation for Animals)

Price

$50 one test per animal
$30 as additional test (same animal)
$45 for 3 or more dogs

Panels Available
Additional Details

Exercise-Induced Collapse (EIC) is a genetic neuromuscular disorder characterized by muscle weakness, lack of coordination and life-threatening collapse after intense exercise in otherwise apparently healthy dogs. Affected dogs tolerate mild to moderate activity but will display signs of EIC after 5-20 minutes of strenuous exercise. The severity of EIC varies, some affected dogs continue to run while dragging their hind legs while others have progression of weakness from rear to forelimbs resulting in a total inability to move. EIC events are often accompanied by a dramatic elevation of body temperature, although unaffected dogs also exhibit elevated temperatures under the same exercise conditions. EIC episodes last from 5-25 minutes with a gradual return to normal with no apparent residual weakness or stiffness. Affected dogs show signs of the disorder as early as 5 months of age, which is typically when more strenuous training and activity begins. Dogs with EIC can lead full, productive lives with proper management. Owners of affected dogs should familiarize themselves with the types of activities that are appropriate for their dogs as well as specific triggers of EIC episodes.

EIC is caused by a mutation in dynamin 1 gene (DNM1 c.767G>T). It is inherited as an autosomal recessive disorder, which means that both males and females are affected equally, and that two copies of the mutation are needed to cause the disease. Dogs with one copy of the normal gene and one copy of the mutation (carriers) do not exhibit any signs of EIC.

Testing for EIC assists clinicians with diagnosis of EIC and helps breeders identify carriers among breeding stock to avoid producing affected dogs. Matings between carriers are expected to produce 25% of affected puppies.

Turnaround Time
5-10 business days

Species

Dog

Type of Test

Results Reported As
Test Result Exercise-Induced Collapse

N/N

No copies of EIC mutation detected. Dog is normal.

N/EIC

1 copy of the EIC mutation detected. Dog is a carrier and unaffected. If bred to another carrier, 25% of offpring are predicted to be affected.

EIC/EIC

2 copies of the EIC mutation detected. Dog is affected and may exhibit exercise-induced collapse under intense activity.

References

Patterson, E.E., Minor, K.M., Tchernatynskaia, A.V., Taylor, S.M., Shelton, G.D., Ekenstedt, K.J., & Mickelson, J.R. (2008). A canine DNM1 mutation is highly associated with the syndrome of exercise-induced collapse. Nature Genetics 40(10), 1235-1239. doi: 10.1038/ng.224

Minor, K.M., Patterson, E.E., Keating, M.K., Gross, S.D., Ekenstedt, K.J., Taylor, S.M., & Mickelson, J.R. (2011). Presence and impact of the exercise-induced collapse associated DNM1 mutation in Labrador retrievers and other breeds. The Veterinary Journal, 189(2), 214-219. doi: 10.1016/j.tvjl.2011.06.022